Biology of Human Tumors Preoperative GNAS and KRAS Testing in the Diagnosis of Pancreatic Mucinous Cysts
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چکیده
Background:Management guidelines for pancreatic intraductal papillary mucinous neoplasms (IPMN) andmucinous cystic neoplasms (MCN) are based on the assumption that mucinous cysts can be accurately distinguished from other pancreatic cystic lesions. Previous studies using surgical material have identified recurrent mutations in GNAS and KRAS in pancreatic mucinous neoplasms. Yet, the diagnostic utility of testing for both genes in pancreatic cyst fluid obtained by endoscopic ultrasound–fine-needle aspiration (EUS–FNA) remains unclear. ExperimentalDesign:GNAS andKRAS testingwas performedonEUS–FNApancreatic cyst fluid from91 pancreatic cysts: 41 IPMNs, 9 IPMNs with adenocarcinoma, 16MCNs, 10 cystic pancreatic neuroendocrine tumors (PanNET), 9 serous cystadenomas (SCA), 3 retention cysts, 2 pseudocysts, and 1 lymphoepithelial
منابع مشابه
Preoperative GNAS and KRAS testing in the diagnosis of pancreatic mucinous cysts.
PURPOSE Management guidelines for pancreatic intraductal papillary mucinous neoplasms (IPMN) and mucinous cystic neoplasms (MCN) are based on the assumption that mucinous cysts can be accurately distinguished from other pancreatic cystic lesions. Previous studies using surgical material have identified recurrent mutations in GNAS and KRAS in pancreatic mucinous neoplasms. Yet, the diagnostic ut...
متن کاملDifferential expression of GNAS and KRAS mutations in pancreatic cysts.
CONTEXT KRAS mutations play an important role in pancreatic cancer. GNAS mutations were discovered in intraductal papillary mucinous neoplasms (IPMN). OBJECTIVES Our aim was to identify the frequency of KRAS and GNAS mutations in pancreatic cystic neoplasms and pancreatic ductal adenocarcinoma (PDAC). METHODS Sixty-eight surgically resected formalin fixed, paraffin embedded pancreatic speci...
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BACKGROUND AND AIMS Pancreatic cyst fluid (PCF) CEA has been shown to be the most accurate preoperative test for detection of cystic mucinous neoplasms (CMNs). This study aimed to assess the added value of PCF KRAS mutational analysis to CEA for diagnosis of CMNs. PATIENTS AND METHODS This is a retrospective study of prospectively collected endoscopic ultrasonography (EUS) fine-needle aspirat...
متن کاملEndoscopic ultrasound guided - fine needle aspiration (EUS-FNA), in comparison with gross and histologic diagnoses of pancreatic lesions
EUS-FNA of the pancreas is the preferred method of investigating and diagnosing pancreatic masses, both solid and cystic. Most solid tumors of the pancreas are conventional pancreatic ductal adenocarcinomas (PDAC). EUS-FNA has a variable sensitivity but high specificity in the preoperative diagnosis of pancreatic lesions, although the diagnosis for well differentiated PDAC is much more challeng...
متن کاملKRAS, GNAS, and RNF43 mutations in intraductal papillary mucinous neoplasm of the pancreas: a meta-analysis
BACKGROUND The prevalence and clinical significances of KRAS, GNAS, and RNF43 mutations in patients with pancreatic intraductal papillary mucinous neoplasm (IPMN) remain elusive. To evaluate the incidence of the gene mutations and clinicopathologic differences between KRAS and GNAS mutations in pancreatic cystic lesions, we performed a meta-analysis of published 33 KRAS, 11 GNAS, and 4 RNF43 st...
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تاریخ انتشار 2014